diff --git a/pkgs/python-packages.nix b/pkgs/python-packages.nix
--- a/pkgs/python-packages.nix
+++ b/pkgs/python-packages.nix
@@ -928,14 +928,14 @@ self: super: {
     };
   };
   "zope.interface" = super.buildPythonPackage {
-    name = "zope.interface-4.5.0";
+    name = "zope.interface-4.6.0";
     doCheck = false;
     propagatedBuildInputs = [
       self."setuptools"
     ];
     src = fetchurl {
-      url = "https://files.pythonhosted.org/packages/ac/8a/657532df378c2cd2a1fe6b12be3b4097521570769d4852ec02c24bd3594e/zope.interface-4.5.0.tar.gz";
-      sha256 = "0k67m60ij06wkg82n15qgyn96waf4pmrkhv0njpkfzpmv5q89hsp";
+      url = "https://files.pythonhosted.org/packages/4e/d0/c9d16bd5b38de44a20c6dc5d5ed80a49626fafcb3db9f9efdc2a19026db6/zope.interface-4.6.0.tar.gz";
+      sha256 = "1rgh2x3rcl9r0v0499kf78xy86rnmanajf4ywmqb943wpk50sg8v";
     };
     meta = {
       license = [ pkgs.lib.licenses.zpl21 ];
diff --git a/requirements.txt b/requirements.txt
--- a/requirements.txt
+++ b/requirements.txt
@@ -26,8 +26,8 @@ subvertpy==0.10.1
 six==1.11.0
 translationstring==1.3
 webob==1.8.4
-zope.interface==4.5.0
 zope.deprecation==4.4.0
+zope.interface==4.6.0
 
 ## http servers
 gevent==1.4.0