diff --git a/IPython/core/interactiveshell.py b/IPython/core/interactiveshell.py
index b78654e..0722cdb 100644
--- a/IPython/core/interactiveshell.py
+++ b/IPython/core/interactiveshell.py
@@ -54,6 +54,7 @@ from IPython.core.profiledir import ProfileDir
 from IPython.core.prompts import PromptManager
 from IPython.core.usage import default_banner
 from IPython.lib.latextools import LaTeXTool
+from IPython.lib.security import InputRejected
 from IPython.testing.skipdoctest import skip_doctest
 from IPython.utils import PyColorize
 from IPython.utils import io
@@ -2786,7 +2787,13 @@ class InteractiveShell(SingletonConfigurable):
                     return None
 
                 # Apply AST transformations
-                code_ast = self.transform_ast(code_ast)
+                try:
+                    code_ast = self.transform_ast(code_ast)
+                except InputRejected:
+                    self.showtraceback()
+                    if store_history:
+                        self.execution_count += 1
+                    return None
 
                 # Execute the user code
                 interactivity = "none" if silent else self.ast_node_interactivity
@@ -2822,6 +2829,11 @@ class InteractiveShell(SingletonConfigurable):
         for transformer in self.ast_transformers:
             try:
                 node = transformer.visit(node)
+            except InputRejected:
+                # User-supplied AST transformers can reject an input by raising
+                # an InputRejected.  Short-circuit in this case so that we
+                # don't unregister the transform.
+                raise
             except Exception:
                 warn("AST transformer %r threw an error. It will be unregistered." % transformer)
                 self.ast_transformers.remove(transformer)
diff --git a/IPython/core/tests/test_interactiveshell.py b/IPython/core/tests/test_interactiveshell.py
index cc3ce21..326a84b 100644
--- a/IPython/core/tests/test_interactiveshell.py
+++ b/IPython/core/tests/test_interactiveshell.py
@@ -25,6 +25,7 @@ from os.path import join
 import nose.tools as nt
 
 from IPython.core.inputtransformer import InputTransformer
+from IPython.lib.security import InputRejected
 from IPython.testing.decorators import (
     skipif, skip_win32, onlyif_unicode_paths, onlyif_cmds_exist,
 )
@@ -695,6 +696,41 @@ class TestAstTransformError(unittest.TestCase):
         # This should have been removed.
         nt.assert_not_in(err_transformer, ip.ast_transformers)
 
+
+class StringRejector(ast.NodeTransformer):
+    """Throws an InputRejected when it sees a string literal.
+
+    Used to verify that NodeTransformers can signal that a piece of code should
+    not be executed by throwing an InputRejected.
+    """
+
+    def visit_Str(self, node):
+        raise InputRejected("test")
+
+
+class TestAstTransformInputRejection(unittest.TestCase):
+
+    def setUp(self):
+        self.transformer = StringRejector()
+        ip.ast_transformers.append(self.transformer)
+
+    def tearDown(self):
+        ip.ast_transformers.remove(self.transformer)
+
+    def test_input_rejection(self):
+        """Check that NodeTransformers can reject input."""
+
+        expect_exception_tb = tt.AssertPrints("InputRejected: test")
+        expect_no_cell_output = tt.AssertNotPrints("'unsafe'", suppress=False)
+
+        # Run the same check twice to verify that the transformer is not
+        # disabled after raising.
+        with expect_exception_tb, expect_no_cell_output:
+            ip.run_cell("'unsafe'")
+
+        with expect_exception_tb, expect_no_cell_output:
+            ip.run_cell("'unsafe'")
+
 def test__IPYTHON__():
     # This shouldn't raise a NameError, that's all
     __IPYTHON__
diff --git a/IPython/lib/security.py b/IPython/lib/security.py
index eab67bb..564410d 100644
--- a/IPython/lib/security.py
+++ b/IPython/lib/security.py
@@ -114,3 +114,13 @@ def passwd_check(hashed_passphrase, passphrase):
     h.update(cast_bytes(passphrase, 'utf-8') + cast_bytes(salt, 'ascii'))
 
     return h.hexdigest() == pw_digest
+
+#-----------------------------------------------------------------------------
+# Exception classes
+#-----------------------------------------------------------------------------
+class InputRejected(Exception):
+    """Input rejected by ast transformer.
+
+    To be raised by user-supplied ast.NodeTransformers when an input should not
+    be executed.
+    """