diff --git a/IPython/terminal/interactiveshell.py b/IPython/terminal/interactiveshell.py
index b5fc148..41a3321 100644
--- a/IPython/terminal/interactiveshell.py
+++ b/IPython/terminal/interactiveshell.py
@@ -16,6 +16,7 @@ from traitlets import (
     Unicode,
     Dict,
     Integer,
+    List,
     observe,
     Instance,
     Type,
@@ -29,7 +30,7 @@ from traitlets import (
 
 from prompt_toolkit.auto_suggest import AutoSuggestFromHistory
 from prompt_toolkit.enums import DEFAULT_BUFFER, EditingMode
-from prompt_toolkit.filters import (HasFocus, Condition, IsDone)
+from prompt_toolkit.filters import HasFocus, Condition, IsDone
 from prompt_toolkit.formatted_text import PygmentsTokens
 from prompt_toolkit.history import History
 from prompt_toolkit.layout.processors import ConditionalProcessor, HighlightMatchingBracketProcessor
@@ -49,7 +50,13 @@ from .magics import TerminalMagics
 from .pt_inputhooks import get_inputhook_name_and_func
 from .prompts import Prompts, ClassicPrompts, RichPromptDisplayHook
 from .ptutils import IPythonPTCompleter, IPythonPTLexer
-from .shortcuts import create_ipython_shortcuts
+from .shortcuts import (
+    create_ipython_shortcuts,
+    create_identifier,
+    RuntimeBinding,
+    add_binding,
+)
+from .shortcuts.filters import KEYBINDING_FILTERS, filter_from_string
 from .shortcuts.auto_suggest import (
     NavigableAutoSuggestFromHistory,
     AppendAutoSuggestionInAnyLine,
@@ -415,6 +422,165 @@ class TerminalInteractiveShell(InteractiveShell):
         provider = change.new
         self._set_autosuggestions(provider)
 
+    shortcuts = List(
+        trait=Dict(
+            key_trait=Enum(
+                [
+                    "command",
+                    "match_keys",
+                    "match_filter",
+                    "new_keys",
+                    "new_filter",
+                    "create",
+                ]
+            ),
+            per_key_traits={
+                "command": Unicode(),
+                "match_keys": List(Unicode()),
+                "match_filter": Unicode(),
+                "new_keys": List(Unicode()),
+                "new_filter": Unicode(),
+                "create": Bool(False),
+            },
+        ),
+        help="""Add, disable or modifying shortcuts.
+
+        Each entry on the list should be a dictionary with ``command`` key
+        identifying the target function executed by the shortcut and at least
+        one of the following:
+
+        - ``match_keys``: list of keys used to match an existing shortcut,
+        - ``match_filter``: shortcut filter used to match an existing shortcut,
+        - ``new_keys``: list of keys to set,
+        - ``new_filter``: a new shortcut filter to set
+
+        The filters have to be composed of pre-defined verbs and joined by one
+        of the following conjunctions: ``&`` (and), ``|`` (or), ``~`` (not).
+        The pre-defined verbs are:
+
+        {}
+
+
+        To disable a shortcut set ``new_keys`` to an empty list.
+        To add a shortcut add key ``create`` with value ``True``.
+
+        When modifying/disabling shortcuts, ``match_keys``/``match_filter`` can
+        be omitted if the provided specification uniquely identifies a shortcut
+        to be modified/disabled. When modifying a shortcut ``new_filter`` or
+        ``new_keys`` can be omitted which will result in reuse of the existing
+        filter/keys.
+
+        Only shortcuts defined in IPython (and not default prompt-toolkit
+        shortcuts) can be modified or disabled. The full list of shortcuts,
+        command identifiers and filters is available under
+        :ref:`terminal-shortcuts-list`.
+        """.format(
+            "\n        ".join([f"- `{k}`" for k in KEYBINDING_FILTERS])
+        ),
+    ).tag(config=True)
+
+    @observe("shortcuts")
+    def _shortcuts_changed(self, change):
+        if self.pt_app:
+            self.pt_app.key_bindings = self._merge_shortcuts(user_shortcuts=change.new)
+
+    def _merge_shortcuts(self, user_shortcuts):
+        # rebuild the bindings list from scratch
+        key_bindings = create_ipython_shortcuts(self)
+
+        # for now we only allow adding shortcuts for commands which are already
+        # registered; this is a security precaution.
+        known_commands = {
+            create_identifier(binding.handler): binding.handler
+            for binding in key_bindings.bindings
+        }
+        shortcuts_to_skip = []
+        shortcuts_to_add = []
+
+        for shortcut in user_shortcuts:
+            command_id = shortcut["command"]
+            if command_id not in known_commands:
+                allowed_commands = "\n - ".join(known_commands)
+                raise ValueError(
+                    f"{command_id} is not a known shortcut command."
+                    f" Allowed commands are: \n - {allowed_commands}"
+                )
+            old_keys = shortcut.get("match_keys", None)
+            old_filter = (
+                filter_from_string(shortcut["match_filter"])
+                if "match_filter" in shortcut
+                else None
+            )
+            matching = [
+                binding
+                for binding in key_bindings.bindings
+                if (
+                    (old_filter is None or binding.filter == old_filter)
+                    and (old_keys is None or [k for k in binding.keys] == old_keys)
+                    and create_identifier(binding.handler) == command_id
+                )
+            ]
+
+            new_keys = shortcut.get("new_keys", None)
+            new_filter = shortcut.get("new_filter", None)
+
+            command = known_commands[command_id]
+
+            creating_new = shortcut.get("create", False)
+            modifying_existing = not creating_new and (
+                new_keys is not None or new_filter
+            )
+
+            if creating_new and new_keys == []:
+                raise ValueError("Cannot add a shortcut without keys")
+
+            if modifying_existing:
+                specification = {
+                    key: shortcut[key]
+                    for key in ["command", "filter"]
+                    if key in shortcut
+                }
+                if len(matching) == 0:
+                    raise ValueError(f"No shortcuts matching {specification} found")
+                elif len(matching) > 1:
+                    raise ValueError(
+                        f"Multiple shortcuts matching {specification} found,"
+                        f" please add keys/filter to select one of: {matching}"
+                    )
+
+                matched = matching[0]
+                old_filter = matched.filter
+                old_keys = list(matched.keys)
+                shortcuts_to_skip.append(
+                    RuntimeBinding(
+                        command,
+                        keys=old_keys,
+                        filter=old_filter,
+                    )
+                )
+
+            if new_keys != []:
+                shortcuts_to_add.append(
+                    RuntimeBinding(
+                        command,
+                        keys=new_keys or old_keys,
+                        filter=filter_from_string(new_filter)
+                        if new_filter is not None
+                        else (
+                            old_filter
+                            if old_filter is not None
+                            else filter_from_string("always")
+                        ),
+                    )
+                )
+
+        # rebuild the bindings list from scratch
+        key_bindings = create_ipython_shortcuts(self, skip=shortcuts_to_skip)
+        for binding in shortcuts_to_add:
+            add_binding(key_bindings, binding)
+
+        return key_bindings
+
     prompt_includes_vi_mode = Bool(True,
         help="Display the current vi mode (when using vi editing mode)."
     ).tag(config=True)
@@ -452,8 +618,7 @@ class TerminalInteractiveShell(InteractiveShell):
             return
 
         # Set up keyboard shortcuts
-        key_bindings = create_ipython_shortcuts(self)
-
+        key_bindings = self._merge_shortcuts(user_shortcuts=self.shortcuts)
 
         # Pre-populate history from IPython's history database
         history = PtkHistoryAdapter(self)
@@ -477,7 +642,7 @@ class TerminalInteractiveShell(InteractiveShell):
             enable_open_in_editor=self.extra_open_editor_shortcuts,
             color_depth=self.color_depth,
             tempfile_suffix=".py",
-            **self._extra_prompt_options()
+            **self._extra_prompt_options(),
         )
         if isinstance(self.auto_suggest, NavigableAutoSuggestFromHistory):
             self.auto_suggest.connect(self.pt_app)
diff --git a/IPython/terminal/shortcuts/__init__.py b/IPython/terminal/shortcuts/__init__.py
index 7ec9a28..9711c81 100644
--- a/IPython/terminal/shortcuts/__init__.py
+++ b/IPython/terminal/shortcuts/__init__.py
@@ -7,414 +7,269 @@ Module to define and register Terminal IPython shortcuts with
 # Distributed under the terms of the Modified BSD License.
 
 import os
-import re
 import signal
 import sys
 import warnings
-from typing import Callable, Dict, Union
+from dataclasses import dataclass
+from typing import Callable, Any, Optional, List
 
 from prompt_toolkit.application.current import get_app
-from prompt_toolkit.enums import DEFAULT_BUFFER, SEARCH_BUFFER
-from prompt_toolkit.filters import Condition, emacs_insert_mode, has_completions
-from prompt_toolkit.filters import has_focus as has_focus_impl
-from prompt_toolkit.filters import (
-    has_selection,
-    has_suggestion,
-    vi_insert_mode,
-    vi_mode,
-)
 from prompt_toolkit.key_binding import KeyBindings
+from prompt_toolkit.key_binding.key_processor import KeyPressEvent
 from prompt_toolkit.key_binding.bindings import named_commands as nc
 from prompt_toolkit.key_binding.bindings.completion import (
     display_completions_like_readline,
 )
 from prompt_toolkit.key_binding.vi_state import InputMode, ViState
-from prompt_toolkit.layout.layout import FocusableElement
+from prompt_toolkit.filters import Condition
 
+from IPython.core.getipython import get_ipython
 from IPython.terminal.shortcuts import auto_match as match
 from IPython.terminal.shortcuts import auto_suggest
+from IPython.terminal.shortcuts.filters import filter_from_string
 from IPython.utils.decorators import undoc
 
 __all__ = ["create_ipython_shortcuts"]
 
 
-@undoc
-@Condition
-def cursor_in_leading_ws():
-    before = get_app().current_buffer.document.current_line_before_cursor
-    return (not before) or before.isspace()
-
-
-def has_focus(value: FocusableElement):
-    """Wrapper around has_focus adding a nice `__name__` to tester function"""
-    tester = has_focus_impl(value).func
-    tester.__name__ = f"is_focused({value})"
-    return Condition(tester)
-
-
-@undoc
-@Condition
-def has_line_below() -> bool:
-    document = get_app().current_buffer.document
-    return document.cursor_position_row < len(document.lines) - 1
-
-
-@undoc
-@Condition
-def has_line_above() -> bool:
-    document = get_app().current_buffer.document
-    return document.cursor_position_row != 0
-
-
-def create_ipython_shortcuts(shell, for_all_platforms: bool = False) -> KeyBindings:
-    """Set up the prompt_toolkit keyboard shortcuts for IPython.
-
-    Parameters
-    ----------
-    shell: InteractiveShell
-        The current IPython shell Instance
-    for_all_platforms: bool (default false)
-        This parameter is mostly used in generating the documentation
-        to create the shortcut binding for all the platforms, and export
-        them.
-
-    Returns
-    -------
-    KeyBindings
-        the keybinding instance for prompt toolkit.
+@dataclass
+class BaseBinding:
+    command: Callable[[KeyPressEvent], Any]
+    keys: List[str]
 
-    """
-    # Warning: if possible, do NOT define handler functions in the locals
-    # scope of this function, instead define functions in the global
-    # scope, or a separate module, and include a user-friendly docstring
-    # describing the action.
 
-    kb = KeyBindings()
-    insert_mode = vi_insert_mode | emacs_insert_mode
+@dataclass
+class RuntimeBinding(BaseBinding):
+    filter: Condition
 
-    if getattr(shell, "handle_return", None):
-        return_handler = shell.handle_return(shell)
-    else:
-        return_handler = newline_or_execute_outer(shell)
 
-    kb.add("enter", filter=(has_focus(DEFAULT_BUFFER) & ~has_selection & insert_mode))(
-        return_handler
-    )
-
-    @Condition
-    def ebivim():
-        return shell.emacs_bindings_in_vi_insert_mode
-
-    @kb.add(
-        "escape",
-        "enter",
-        filter=(has_focus(DEFAULT_BUFFER) & ~has_selection & insert_mode & ebivim),
-    )
-    def reformat_and_execute(event):
-        """Reformat code and execute it"""
-        reformat_text_before_cursor(
-            event.current_buffer, event.current_buffer.document, shell
-        )
-        event.current_buffer.validate_and_handle()
-
-    kb.add("c-\\")(quit)
-
-    kb.add("c-p", filter=(vi_insert_mode & has_focus(DEFAULT_BUFFER)))(
-        previous_history_or_previous_completion
-    )
-
-    kb.add("c-n", filter=(vi_insert_mode & has_focus(DEFAULT_BUFFER)))(
-        next_history_or_next_completion
-    )
-
-    kb.add("c-g", filter=(has_focus(DEFAULT_BUFFER) & has_completions))(
-        dismiss_completion
-    )
-
-    kb.add("c-c", filter=has_focus(DEFAULT_BUFFER))(reset_buffer)
-
-    kb.add("c-c", filter=has_focus(SEARCH_BUFFER))(reset_search_buffer)
-
-    supports_suspend = Condition(lambda: hasattr(signal, "SIGTSTP"))
-    kb.add("c-z", filter=supports_suspend)(suspend_to_bg)
-
-    # Ctrl+I == Tab
-    kb.add(
-        "tab",
-        filter=(
-            has_focus(DEFAULT_BUFFER)
-            & ~has_selection
-            & insert_mode
-            & cursor_in_leading_ws
-        ),
-    )(indent_buffer)
-    kb.add("c-o", filter=(has_focus(DEFAULT_BUFFER) & emacs_insert_mode))(
-        newline_autoindent_outer(shell.input_transformer_manager)
-    )
-
-    kb.add("f2", filter=has_focus(DEFAULT_BUFFER))(open_input_in_editor)
-
-    @Condition
-    def auto_match():
-        return shell.auto_match
-
-    def all_quotes_paired(quote, buf):
-        paired = True
-        i = 0
-        while i < len(buf):
-            c = buf[i]
-            if c == quote:
-                paired = not paired
-            elif c == "\\":
-                i += 1
-            i += 1
-        return paired
-
-    focused_insert = (vi_insert_mode | emacs_insert_mode) & has_focus(DEFAULT_BUFFER)
-    _preceding_text_cache: Dict[Union[str, Callable], Condition] = {}
-    _following_text_cache: Dict[Union[str, Callable], Condition] = {}
-
-    def preceding_text(pattern: Union[str, Callable]):
-        if pattern in _preceding_text_cache:
-            return _preceding_text_cache[pattern]
-
-        if callable(pattern):
-
-            def _preceding_text():
-                app = get_app()
-                before_cursor = app.current_buffer.document.current_line_before_cursor
-                # mypy can't infer if(callable): https://github.com/python/mypy/issues/3603
-                return bool(pattern(before_cursor))  # type: ignore[operator]
+@dataclass
+class Binding(BaseBinding):
+    # while filter could be created by referencing variables directly (rather
+    # than created from strings), by using strings we ensure that users will
+    # be able to create filters in configuration (e.g. JSON) files too, which
+    # also benefits the documentation by enforcing human-readable filter names.
+    condition: Optional[str] = None
 
+    def __post_init__(self):
+        if self.condition:
+            self.filter = filter_from_string(self.condition)
         else:
-            m = re.compile(pattern)
-
-            def _preceding_text():
-                app = get_app()
-                before_cursor = app.current_buffer.document.current_line_before_cursor
-                return bool(m.match(before_cursor))
-
-            _preceding_text.__name__ = f"preceding_text({pattern!r})"
-
-        condition = Condition(_preceding_text)
-        _preceding_text_cache[pattern] = condition
-        return condition
-
-    def following_text(pattern):
-        try:
-            return _following_text_cache[pattern]
-        except KeyError:
-            pass
-        m = re.compile(pattern)
-
-        def _following_text():
-            app = get_app()
-            return bool(m.match(app.current_buffer.document.current_line_after_cursor))
-
-        _following_text.__name__ = f"following_text({pattern!r})"
+            self.filter = None
 
-        condition = Condition(_following_text)
-        _following_text_cache[pattern] = condition
-        return condition
 
-    @Condition
-    def not_inside_unclosed_string():
-        app = get_app()
-        s = app.current_buffer.document.text_before_cursor
-        # remove escaped quotes
-        s = s.replace('\\"', "").replace("\\'", "")
-        # remove triple-quoted string literals
-        s = re.sub(r"(?:\"\"\"[\s\S]*\"\"\"|'''[\s\S]*''')", "", s)
-        # remove single-quoted string literals
-        s = re.sub(r"""(?:"[^"]*["\n]|'[^']*['\n])""", "", s)
-        return not ('"' in s or "'" in s)
-
-    # auto match
-    for key, cmd in match.auto_match_parens.items():
-        kb.add(key, filter=focused_insert & auto_match & following_text(r"[,)}\]]|$"))(
-            cmd
-        )
+def create_identifier(handler: Callable):
+    parts = handler.__module__.split(".")
+    name = handler.__name__
+    package = parts[0]
+    if len(parts) > 1:
+        final_module = parts[-1]
+        return f"{package}:{final_module}.{name}"
+    else:
+        return f"{package}:{name}"
 
-    # raw string
-    for key, cmd in match.auto_match_parens_raw_string.items():
-        kb.add(
-            key,
-            filter=focused_insert & auto_match & preceding_text(r".*(r|R)[\"'](-*)$"),
-        )(cmd)
-
-    kb.add(
-        '"',
-        filter=focused_insert
-        & auto_match
-        & not_inside_unclosed_string
-        & preceding_text(lambda line: all_quotes_paired('"', line))
-        & following_text(r"[,)}\]]|$"),
-    )(match.double_quote)
-
-    kb.add(
-        "'",
-        filter=focused_insert
-        & auto_match
-        & not_inside_unclosed_string
-        & preceding_text(lambda line: all_quotes_paired("'", line))
-        & following_text(r"[,)}\]]|$"),
-    )(match.single_quote)
-
-    kb.add(
-        '"',
-        filter=focused_insert
-        & auto_match
-        & not_inside_unclosed_string
-        & preceding_text(r'^.*""$'),
-    )(match.docstring_double_quotes)
-
-    kb.add(
-        "'",
-        filter=focused_insert
-        & auto_match
-        & not_inside_unclosed_string
-        & preceding_text(r"^.*''$"),
-    )(match.docstring_single_quotes)
-
-    # just move cursor
-    kb.add(")", filter=focused_insert & auto_match & following_text(r"^\)"))(
-        match.skip_over
-    )
-    kb.add("]", filter=focused_insert & auto_match & following_text(r"^\]"))(
-        match.skip_over
-    )
-    kb.add("}", filter=focused_insert & auto_match & following_text(r"^\}"))(
-        match.skip_over
-    )
-    kb.add('"', filter=focused_insert & auto_match & following_text('^"'))(
-        match.skip_over
-    )
-    kb.add("'", filter=focused_insert & auto_match & following_text("^'"))(
-        match.skip_over
-    )
 
-    kb.add(
-        "backspace",
-        filter=focused_insert
-        & preceding_text(r".*\($")
-        & auto_match
-        & following_text(r"^\)"),
-    )(match.delete_pair)
-    kb.add(
-        "backspace",
-        filter=focused_insert
-        & preceding_text(r".*\[$")
-        & auto_match
-        & following_text(r"^\]"),
-    )(match.delete_pair)
-    kb.add(
-        "backspace",
-        filter=focused_insert
-        & preceding_text(r".*\{$")
-        & auto_match
-        & following_text(r"^\}"),
-    )(match.delete_pair)
-    kb.add(
-        "backspace",
-        filter=focused_insert
-        & preceding_text('.*"$')
-        & auto_match
-        & following_text('^"'),
-    )(match.delete_pair)
-    kb.add(
-        "backspace",
-        filter=focused_insert
-        & preceding_text(r".*'$")
-        & auto_match
-        & following_text(r"^'"),
-    )(match.delete_pair)
-
-    if shell.display_completions == "readlinelike":
-        kb.add(
-            "c-i",
-            filter=(
-                has_focus(DEFAULT_BUFFER)
-                & ~has_selection
-                & insert_mode
-                & ~cursor_in_leading_ws
-            ),
-        )(display_completions_like_readline)
-
-    if sys.platform == "win32" or for_all_platforms:
-        kb.add("c-v", filter=(has_focus(DEFAULT_BUFFER) & ~vi_mode))(win_paste)
-
-    focused_insert_vi = has_focus(DEFAULT_BUFFER) & vi_insert_mode
-
-    # autosuggestions
-    @Condition
-    def navigable_suggestions():
-        return isinstance(
-            shell.auto_suggest, auto_suggest.NavigableAutoSuggestFromHistory
+AUTO_MATCH_BINDINGS = [
+    *[
+        Binding(
+            cmd, [key], "focused_insert & auto_match & followed_by_closing_paren_or_end"
         )
-
-    kb.add("end", filter=has_focus(DEFAULT_BUFFER) & (ebivim | ~vi_insert_mode))(
-        auto_suggest.accept_in_vi_insert_mode
-    )
-    kb.add("c-e", filter=focused_insert_vi & ebivim)(
-        auto_suggest.accept_in_vi_insert_mode
-    )
-    kb.add("c-f", filter=focused_insert_vi)(auto_suggest.accept)
-    kb.add("escape", "f", filter=focused_insert_vi & ebivim)(auto_suggest.accept_word)
-    kb.add("c-right", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
-        auto_suggest.accept_token
-    )
-    kb.add(
-        "escape", filter=has_suggestion & has_focus(DEFAULT_BUFFER) & emacs_insert_mode
-    )(auto_suggest.discard)
-    kb.add(
-        "up",
-        filter=navigable_suggestions
-        & ~has_line_above
-        & has_suggestion
-        & has_focus(DEFAULT_BUFFER),
-    )(auto_suggest.swap_autosuggestion_up(shell.auto_suggest))
-    kb.add(
-        "down",
-        filter=navigable_suggestions
-        & ~has_line_below
-        & has_suggestion
-        & has_focus(DEFAULT_BUFFER),
-    )(auto_suggest.swap_autosuggestion_down(shell.auto_suggest))
-    kb.add(
-        "up", filter=has_line_above & navigable_suggestions & has_focus(DEFAULT_BUFFER)
-    )(auto_suggest.up_and_update_hint)
-    kb.add(
-        "down",
-        filter=has_line_below & navigable_suggestions & has_focus(DEFAULT_BUFFER),
-    )(auto_suggest.down_and_update_hint)
-    kb.add("right", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
-        auto_suggest.accept_character
-    )
-    kb.add("c-left", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
-        auto_suggest.accept_and_move_cursor_left
-    )
-    kb.add("c-down", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
-        auto_suggest.accept_and_keep_cursor
-    )
-    kb.add("backspace", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
-        auto_suggest.backspace_and_resume_hint
-    )
-
-    # Simple Control keybindings
-    key_cmd_dict = {
+        for key, cmd in match.auto_match_parens.items()
+    ],
+    *[
+        # raw string
+        Binding(cmd, [key], "focused_insert & auto_match & preceded_by_raw_str_prefix")
+        for key, cmd in match.auto_match_parens_raw_string.items()
+    ],
+    Binding(
+        match.double_quote,
+        ['"'],
+        "focused_insert"
+        " & auto_match"
+        " & not_inside_unclosed_string"
+        " & preceded_by_paired_double_quotes"
+        " & followed_by_closing_paren_or_end",
+    ),
+    Binding(
+        match.single_quote,
+        ["'"],
+        "focused_insert"
+        " & auto_match"
+        " & not_inside_unclosed_string"
+        " & preceded_by_paired_single_quotes"
+        " & followed_by_closing_paren_or_end",
+    ),
+    Binding(
+        match.docstring_double_quotes,
+        ['"'],
+        "focused_insert"
+        " & auto_match"
+        " & not_inside_unclosed_string"
+        " & preceded_by_two_double_quotes",
+    ),
+    Binding(
+        match.docstring_single_quotes,
+        ["'"],
+        "focused_insert"
+        " & auto_match"
+        " & not_inside_unclosed_string"
+        " & preceded_by_two_single_quotes",
+    ),
+    Binding(
+        match.skip_over,
+        [")"],
+        "focused_insert & auto_match & followed_by_closing_round_paren",
+    ),
+    Binding(
+        match.skip_over,
+        ["]"],
+        "focused_insert & auto_match & followed_by_closing_bracket",
+    ),
+    Binding(
+        match.skip_over,
+        ["}"],
+        "focused_insert & auto_match & followed_by_closing_brace",
+    ),
+    Binding(
+        match.skip_over, ['"'], "focused_insert & auto_match & followed_by_double_quote"
+    ),
+    Binding(
+        match.skip_over, ["'"], "focused_insert & auto_match & followed_by_single_quote"
+    ),
+    Binding(
+        match.delete_pair,
+        ["backspace"],
+        "focused_insert"
+        " & preceded_by_opening_round_paren"
+        " & auto_match"
+        " & followed_by_closing_round_paren",
+    ),
+    Binding(
+        match.delete_pair,
+        ["backspace"],
+        "focused_insert"
+        " & preceded_by_opening_bracket"
+        " & auto_match"
+        " & followed_by_closing_bracket",
+    ),
+    Binding(
+        match.delete_pair,
+        ["backspace"],
+        "focused_insert"
+        " & preceded_by_opening_brace"
+        " & auto_match"
+        " & followed_by_closing_brace",
+    ),
+    Binding(
+        match.delete_pair,
+        ["backspace"],
+        "focused_insert"
+        " & preceded_by_double_quote"
+        " & auto_match"
+        " & followed_by_double_quote",
+    ),
+    Binding(
+        match.delete_pair,
+        ["backspace"],
+        "focused_insert"
+        " & preceded_by_single_quote"
+        " & auto_match"
+        " & followed_by_single_quote",
+    ),
+]
+
+AUTO_SUGGEST_BINDINGS = [
+    Binding(
+        auto_suggest.accept_in_vi_insert_mode,
+        ["end"],
+        "default_buffer_focused & (ebivim | ~vi_insert_mode)",
+    ),
+    Binding(
+        auto_suggest.accept_in_vi_insert_mode,
+        ["c-e"],
+        "vi_insert_mode & default_buffer_focused & ebivim",
+    ),
+    Binding(auto_suggest.accept, ["c-f"], "vi_insert_mode & default_buffer_focused"),
+    Binding(
+        auto_suggest.accept_word,
+        ["escape", "f"],
+        "vi_insert_mode & default_buffer_focused & ebivim",
+    ),
+    Binding(
+        auto_suggest.accept_token,
+        ["c-right"],
+        "has_suggestion & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.discard,
+        ["escape"],
+        "has_suggestion & default_buffer_focused & emacs_insert_mode",
+    ),
+    Binding(
+        auto_suggest.swap_autosuggestion_up,
+        ["up"],
+        "navigable_suggestions"
+        " & ~has_line_above"
+        " & has_suggestion"
+        " & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.swap_autosuggestion_down,
+        ["down"],
+        "navigable_suggestions"
+        " & ~has_line_below"
+        " & has_suggestion"
+        " & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.up_and_update_hint,
+        ["up"],
+        "has_line_above & navigable_suggestions & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.down_and_update_hint,
+        ["down"],
+        "has_line_below & navigable_suggestions & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.accept_character,
+        ["escape", "right"],
+        "has_suggestion & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.accept_and_move_cursor_left,
+        ["c-left"],
+        "has_suggestion & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.accept_and_keep_cursor,
+        ["c-down"],
+        "has_suggestion & default_buffer_focused",
+    ),
+    Binding(
+        auto_suggest.backspace_and_resume_hint,
+        ["backspace"],
+        "has_suggestion & default_buffer_focused",
+    ),
+]
+
+
+SIMPLE_CONTROL_BINDINGS = [
+    Binding(cmd, [key], "vi_insert_mode & default_buffer_focused & ebivim")
+    for key, cmd in {
         "c-a": nc.beginning_of_line,
         "c-b": nc.backward_char,
         "c-k": nc.kill_line,
         "c-w": nc.backward_kill_word,
         "c-y": nc.yank,
         "c-_": nc.undo,
-    }
+    }.items()
+]
 
-    for key, cmd in key_cmd_dict.items():
-        kb.add(key, filter=focused_insert_vi & ebivim)(cmd)
 
-    # Alt and Combo Control keybindings
-    keys_cmd_dict = {
+ALT_AND_COMOBO_CONTROL_BINDINGS = [
+    Binding(cmd, list(keys), "vi_insert_mode & default_buffer_focused & ebivim")
+    for keys, cmd in {
         # Control Combos
         ("c-x", "c-e"): nc.edit_and_execute,
         ("c-x", "e"): nc.edit_and_execute,
@@ -427,10 +282,48 @@ def create_ipython_shortcuts(shell, for_all_platforms: bool = False) -> KeyBindi
         ("escape", "u"): nc.uppercase_word,
         ("escape", "y"): nc.yank_pop,
         ("escape", "."): nc.yank_last_arg,
-    }
+    }.items()
+]
+
+
+def add_binding(bindings: KeyBindings, binding: Binding):
+    bindings.add(
+        *binding.keys,
+        **({"filter": binding.filter} if binding.filter is not None else {}),
+    )(binding.command)
+
+
+def create_ipython_shortcuts(shell, skip=None) -> KeyBindings:
+    """Set up the prompt_toolkit keyboard shortcuts for IPython.
 
-    for keys, cmd in keys_cmd_dict.items():
-        kb.add(*keys, filter=focused_insert_vi & ebivim)(cmd)
+    Parameters
+    ----------
+    shell: InteractiveShell
+        The current IPython shell Instance
+    skip: List[Binding]
+        Bindings to skip.
+
+    Returns
+    -------
+    KeyBindings
+        the keybinding instance for prompt toolkit.
+
+    """
+    kb = KeyBindings()
+    skip = skip or []
+    for binding in KEY_BINDINGS:
+        skip_this_one = False
+        for to_skip in skip:
+            if (
+                to_skip.command == binding.command
+                and to_skip.filter == binding.filter
+                and to_skip.keys == binding.keys
+            ):
+                skip_this_one = True
+                break
+        if skip_this_one:
+            continue
+        add_binding(kb, binding)
 
     def get_input_mode(self):
         app = get_app()
@@ -451,9 +344,19 @@ def create_ipython_shortcuts(shell, for_all_platforms: bool = False) -> KeyBindi
     if shell.editing_mode == "vi" and shell.modal_cursor:
         ViState._input_mode = InputMode.INSERT  # type: ignore
         ViState.input_mode = property(get_input_mode, set_input_mode)  # type: ignore
+
     return kb
 
 
+def reformat_and_execute(event):
+    """Reformat code and execute it"""
+    shell = get_ipython()
+    reformat_text_before_cursor(
+        event.current_buffer, event.current_buffer.document, shell
+    )
+    event.current_buffer.validate_and_handle()
+
+
 def reformat_text_before_cursor(buffer, document, shell):
     text = buffer.delete_before_cursor(len(document.text[: document.cursor_position]))
     try:
@@ -463,6 +366,14 @@ def reformat_text_before_cursor(buffer, document, shell):
         buffer.insert_text(text)
 
 
+def handle_return_or_newline_or_execute(event):
+    shell = get_ipython()
+    if getattr(shell, "handle_return", None):
+        return shell.handle_return(shell)(event)
+    else:
+        return newline_or_execute_outer(shell)(event)
+
+
 def newline_or_execute_outer(shell):
     def newline_or_execute(event):
         """When the user presses return, insert a newline or execute the code."""
@@ -512,8 +423,6 @@ def newline_or_execute_outer(shell):
             else:
                 b.insert_text("\n")
 
-    newline_or_execute.__qualname__ = "newline_or_execute"
-
     return newline_or_execute
 
 
@@ -610,30 +519,24 @@ def newline_with_copy_margin(event):
         b.cursor_right(count=pos_diff)
 
 
-def newline_autoindent_outer(inputsplitter) -> Callable[..., None]:
-    """
-    Return a function suitable for inserting a indented newline after the cursor.
+def newline_autoindent(event):
+    """Insert a newline after the cursor indented appropriately.
 
     Fancier version of deprecated ``newline_with_copy_margin`` which should
     compute the correct indentation of the inserted line. That is to say, indent
     by 4 extra space after a function definition, class definition, context
     manager... And dedent by 4 space after ``pass``, ``return``, ``raise ...``.
     """
+    shell = get_ipython()
+    inputsplitter = shell.input_transformer_manager
+    b = event.current_buffer
+    d = b.document
 
-    def newline_autoindent(event):
-        """Insert a newline after the cursor indented appropriately."""
-        b = event.current_buffer
-        d = b.document
-
-        if b.complete_state:
-            b.cancel_completion()
-        text = d.text[: d.cursor_position] + "\n"
-        _, indent = inputsplitter.check_complete(text)
-        b.insert_text("\n" + (" " * (indent or 0)), move_cursor=False)
-
-    newline_autoindent.__qualname__ = "newline_autoindent"
-
-    return newline_autoindent
+    if b.complete_state:
+        b.cancel_completion()
+    text = d.text[: d.cursor_position] + "\n"
+    _, indent = inputsplitter.check_complete(text)
+    b.insert_text("\n" + (" " * (indent or 0)), move_cursor=False)
 
 
 def open_input_in_editor(event):
@@ -666,5 +569,58 @@ else:
 
     @undoc
     def win_paste(event):
-        """Stub used when auto-generating shortcuts for documentation"""
+        """Stub used on other platforms"""
         pass
+
+
+KEY_BINDINGS = [
+    Binding(
+        handle_return_or_newline_or_execute,
+        ["enter"],
+        "default_buffer_focused & ~has_selection & insert_mode",
+    ),
+    Binding(
+        reformat_and_execute,
+        ["escape", "enter"],
+        "default_buffer_focused & ~has_selection & insert_mode & ebivim",
+    ),
+    Binding(quit, ["c-\\"]),
+    Binding(
+        previous_history_or_previous_completion,
+        ["c-p"],
+        "vi_insert_mode & default_buffer_focused",
+    ),
+    Binding(
+        next_history_or_next_completion,
+        ["c-n"],
+        "vi_insert_mode & default_buffer_focused",
+    ),
+    Binding(dismiss_completion, ["c-g"], "default_buffer_focused & has_completions"),
+    Binding(reset_buffer, ["c-c"], "default_buffer_focused"),
+    Binding(reset_search_buffer, ["c-c"], "search_buffer_focused"),
+    Binding(suspend_to_bg, ["c-z"], "supports_suspend"),
+    Binding(
+        indent_buffer,
+        ["tab"],  # Ctrl+I == Tab
+        "default_buffer_focused"
+        " & ~has_selection"
+        " & insert_mode"
+        " & cursor_in_leading_ws",
+    ),
+    Binding(newline_autoindent, ["c-o"], "default_buffer_focused & emacs_insert_mode"),
+    Binding(open_input_in_editor, ["f2"], "default_buffer_focused"),
+    *AUTO_MATCH_BINDINGS,
+    *AUTO_SUGGEST_BINDINGS,
+    Binding(
+        display_completions_like_readline,
+        ["c-i"],
+        "readline_like_completions"
+        " & default_buffer_focused"
+        " & ~has_selection"
+        " & insert_mode"
+        " & ~cursor_in_leading_ws",
+    ),
+    Binding(win_paste, ["c-v"], "default_buffer_focused & ~vi_mode & is_windows_os"),
+    *SIMPLE_CONTROL_BINDINGS,
+    *ALT_AND_COMOBO_CONTROL_BINDINGS,
+]
diff --git a/IPython/terminal/shortcuts/auto_match.py b/IPython/terminal/shortcuts/auto_match.py
index 46cb1bd..6c2b1ef 100644
--- a/IPython/terminal/shortcuts/auto_match.py
+++ b/IPython/terminal/shortcuts/auto_match.py
@@ -1,7 +1,7 @@
 """
-Utilities function for keybinding with prompt toolkit. 
+Utilities function for keybinding with prompt toolkit.
 
-This will be bound to specific key press and filter modes, 
+This will be bound to specific key press and filter modes,
 like whether we are in edit mode, and whether the completer is open.
 """
 import re
@@ -84,9 +84,9 @@ def raw_string_braces(event: KeyPressEvent):
 
 
 def skip_over(event: KeyPressEvent):
-    """Skip over automatically added parenthesis.
+    """Skip over automatically added parenthesis/quote.
 
-    (rather than adding another parenthesis)"""
+    (rather than adding another parenthesis/quote)"""
     event.current_buffer.cursor_right()
 
 
diff --git a/IPython/terminal/shortcuts/auto_suggest.py b/IPython/terminal/shortcuts/auto_suggest.py
index 3bfd6d5..0c193d9 100644
--- a/IPython/terminal/shortcuts/auto_suggest.py
+++ b/IPython/terminal/shortcuts/auto_suggest.py
@@ -1,7 +1,7 @@
 import re
 import tokenize
 from io import StringIO
-from typing import Callable, List, Optional, Union, Generator, Tuple, Sequence
+from typing import Callable, List, Optional, Union, Generator, Tuple
 
 from prompt_toolkit.buffer import Buffer
 from prompt_toolkit.key_binding import KeyPressEvent
@@ -16,6 +16,7 @@ from prompt_toolkit.layout.processors import (
     TransformationInput,
 )
 
+from IPython.core.getipython import get_ipython
 from IPython.utils.tokenutil import generate_tokens
 
 
@@ -346,33 +347,29 @@ def _swap_autosuggestion(
     buffer.suggestion = new_suggestion
 
 
-def swap_autosuggestion_up(provider: Provider):
-    def swap_autosuggestion_up(event: KeyPressEvent):
-        """Get next autosuggestion from history."""
-        if not isinstance(provider, NavigableAutoSuggestFromHistory):
-            return
+def swap_autosuggestion_up(event: KeyPressEvent):
+    """Get next autosuggestion from history."""
+    shell = get_ipython()
+    provider = shell.auto_suggest
 
-        return _swap_autosuggestion(
-            buffer=event.current_buffer, provider=provider, direction_method=provider.up
-        )
+    if not isinstance(provider, NavigableAutoSuggestFromHistory):
+        return
 
-    swap_autosuggestion_up.__name__ = "swap_autosuggestion_up"
-    return swap_autosuggestion_up
+    return _swap_autosuggestion(
+        buffer=event.current_buffer, provider=provider, direction_method=provider.up
+    )
 
 
-def swap_autosuggestion_down(
-    provider: Union[AutoSuggestFromHistory, NavigableAutoSuggestFromHistory, None]
-):
-    def swap_autosuggestion_down(event: KeyPressEvent):
-        """Get previous autosuggestion from history."""
-        if not isinstance(provider, NavigableAutoSuggestFromHistory):
-            return
+def swap_autosuggestion_down(event: KeyPressEvent):
+    """Get previous autosuggestion from history."""
+    shell = get_ipython()
+    provider = shell.auto_suggest
 
-        return _swap_autosuggestion(
-            buffer=event.current_buffer,
-            provider=provider,
-            direction_method=provider.down,
-        )
+    if not isinstance(provider, NavigableAutoSuggestFromHistory):
+        return
 
-    swap_autosuggestion_down.__name__ = "swap_autosuggestion_down"
-    return swap_autosuggestion_down
+    return _swap_autosuggestion(
+        buffer=event.current_buffer,
+        provider=provider,
+        direction_method=provider.down,
+    )
diff --git a/IPython/terminal/shortcuts/filters.py b/IPython/terminal/shortcuts/filters.py
new file mode 100644
index 0000000..a4a6213
--- /dev/null
+++ b/IPython/terminal/shortcuts/filters.py
@@ -0,0 +1,256 @@
+"""
+Filters restricting scope of IPython Terminal shortcuts.
+"""
+
+# Copyright (c) IPython Development Team.
+# Distributed under the terms of the Modified BSD License.
+
+import ast
+import re
+import signal
+import sys
+from typing import Callable, Dict, Union
+
+from prompt_toolkit.application.current import get_app
+from prompt_toolkit.enums import DEFAULT_BUFFER, SEARCH_BUFFER
+from prompt_toolkit.filters import Condition, emacs_insert_mode, has_completions
+from prompt_toolkit.filters import has_focus as has_focus_impl
+from prompt_toolkit.filters import (
+    Always,
+    has_selection,
+    has_suggestion,
+    vi_insert_mode,
+    vi_mode,
+)
+from prompt_toolkit.layout.layout import FocusableElement
+
+from IPython.core.getipython import get_ipython
+from IPython.core.guarded_eval import _find_dunder, BINARY_OP_DUNDERS, UNARY_OP_DUNDERS
+from IPython.terminal.shortcuts import auto_suggest
+from IPython.utils.decorators import undoc
+
+
+@undoc
+@Condition
+def cursor_in_leading_ws():
+    before = get_app().current_buffer.document.current_line_before_cursor
+    return (not before) or before.isspace()
+
+
+def has_focus(value: FocusableElement):
+    """Wrapper around has_focus adding a nice `__name__` to tester function"""
+    tester = has_focus_impl(value).func
+    tester.__name__ = f"is_focused({value})"
+    return Condition(tester)
+
+
+@undoc
+@Condition
+def has_line_below() -> bool:
+    document = get_app().current_buffer.document
+    return document.cursor_position_row < len(document.lines) - 1
+
+
+@undoc
+@Condition
+def has_line_above() -> bool:
+    document = get_app().current_buffer.document
+    return document.cursor_position_row != 0
+
+
+@Condition
+def ebivim():
+    shell = get_ipython()
+    return shell.emacs_bindings_in_vi_insert_mode
+
+
+@Condition
+def supports_suspend():
+    return hasattr(signal, "SIGTSTP")
+
+
+@Condition
+def auto_match():
+    shell = get_ipython()
+    return shell.auto_match
+
+
+def all_quotes_paired(quote, buf):
+    paired = True
+    i = 0
+    while i < len(buf):
+        c = buf[i]
+        if c == quote:
+            paired = not paired
+        elif c == "\\":
+            i += 1
+        i += 1
+    return paired
+
+
+_preceding_text_cache: Dict[Union[str, Callable], Condition] = {}
+_following_text_cache: Dict[Union[str, Callable], Condition] = {}
+
+
+def preceding_text(pattern: Union[str, Callable]):
+    if pattern in _preceding_text_cache:
+        return _preceding_text_cache[pattern]
+
+    if callable(pattern):
+
+        def _preceding_text():
+            app = get_app()
+            before_cursor = app.current_buffer.document.current_line_before_cursor
+            # mypy can't infer if(callable): https://github.com/python/mypy/issues/3603
+            return bool(pattern(before_cursor))  # type: ignore[operator]
+
+    else:
+        m = re.compile(pattern)
+
+        def _preceding_text():
+            app = get_app()
+            before_cursor = app.current_buffer.document.current_line_before_cursor
+            return bool(m.match(before_cursor))
+
+        _preceding_text.__name__ = f"preceding_text({pattern!r})"
+
+    condition = Condition(_preceding_text)
+    _preceding_text_cache[pattern] = condition
+    return condition
+
+
+def following_text(pattern):
+    try:
+        return _following_text_cache[pattern]
+    except KeyError:
+        pass
+    m = re.compile(pattern)
+
+    def _following_text():
+        app = get_app()
+        return bool(m.match(app.current_buffer.document.current_line_after_cursor))
+
+    _following_text.__name__ = f"following_text({pattern!r})"
+
+    condition = Condition(_following_text)
+    _following_text_cache[pattern] = condition
+    return condition
+
+
+@Condition
+def not_inside_unclosed_string():
+    app = get_app()
+    s = app.current_buffer.document.text_before_cursor
+    # remove escaped quotes
+    s = s.replace('\\"', "").replace("\\'", "")
+    # remove triple-quoted string literals
+    s = re.sub(r"(?:\"\"\"[\s\S]*\"\"\"|'''[\s\S]*''')", "", s)
+    # remove single-quoted string literals
+    s = re.sub(r"""(?:"[^"]*["\n]|'[^']*['\n])""", "", s)
+    return not ('"' in s or "'" in s)
+
+
+@Condition
+def navigable_suggestions():
+    shell = get_ipython()
+    return isinstance(shell.auto_suggest, auto_suggest.NavigableAutoSuggestFromHistory)
+
+
+@Condition
+def readline_like_completions():
+    shell = get_ipython()
+    return shell.display_completions == "readlinelike"
+
+
+@Condition
+def is_windows_os():
+    return sys.platform == "win32"
+
+
+# these one is callable and re-used multiple times hence needs to be
+# only defined once beforhand so that transforming back to human-readable
+# names works well in the documentation.
+default_buffer_focused = has_focus(DEFAULT_BUFFER)
+
+KEYBINDING_FILTERS = {
+    "always": Always(),
+    "has_line_below": has_line_below,
+    "has_line_above": has_line_above,
+    "has_selection": has_selection,
+    "has_suggestion": has_suggestion,
+    "vi_mode": vi_mode,
+    "vi_insert_mode": vi_insert_mode,
+    "emacs_insert_mode": emacs_insert_mode,
+    "has_completions": has_completions,
+    "insert_mode": vi_insert_mode | emacs_insert_mode,
+    "default_buffer_focused": default_buffer_focused,
+    "search_buffer_focused": has_focus(SEARCH_BUFFER),
+    "ebivim": ebivim,
+    "supports_suspend": supports_suspend,
+    "is_windows_os": is_windows_os,
+    "auto_match": auto_match,
+    "focused_insert": (vi_insert_mode | emacs_insert_mode) & default_buffer_focused,
+    "not_inside_unclosed_string": not_inside_unclosed_string,
+    "readline_like_completions": readline_like_completions,
+    "preceded_by_paired_double_quotes": preceding_text(
+        lambda line: all_quotes_paired('"', line)
+    ),
+    "preceded_by_paired_single_quotes": preceding_text(
+        lambda line: all_quotes_paired("'", line)
+    ),
+    "preceded_by_raw_str_prefix": preceding_text(r".*(r|R)[\"'](-*)$"),
+    "preceded_by_two_double_quotes": preceding_text(r'^.*""$'),
+    "preceded_by_two_single_quotes": preceding_text(r"^.*''$"),
+    "followed_by_closing_paren_or_end": following_text(r"[,)}\]]|$"),
+    "preceded_by_opening_round_paren": preceding_text(r".*\($"),
+    "preceded_by_opening_bracket": preceding_text(r".*\[$"),
+    "preceded_by_opening_brace": preceding_text(r".*\{$"),
+    "preceded_by_double_quote": preceding_text('.*"$'),
+    "preceded_by_single_quote": preceding_text(r".*'$"),
+    "followed_by_closing_round_paren": following_text(r"^\)"),
+    "followed_by_closing_bracket": following_text(r"^\]"),
+    "followed_by_closing_brace": following_text(r"^\}"),
+    "followed_by_double_quote": following_text('^"'),
+    "followed_by_single_quote": following_text("^'"),
+    "navigable_suggestions": navigable_suggestions,
+    "cursor_in_leading_ws": cursor_in_leading_ws,
+}
+
+
+def eval_node(node: Union[ast.AST, None]):
+    if node is None:
+        return None
+    if isinstance(node, ast.Expression):
+        return eval_node(node.body)
+    if isinstance(node, ast.BinOp):
+        left = eval_node(node.left)
+        right = eval_node(node.right)
+        dunders = _find_dunder(node.op, BINARY_OP_DUNDERS)
+        if dunders:
+            return getattr(left, dunders[0])(right)
+        raise ValueError(f"Unknown binary operation: {node.op}")
+    if isinstance(node, ast.UnaryOp):
+        value = eval_node(node.operand)
+        dunders = _find_dunder(node.op, UNARY_OP_DUNDERS)
+        if dunders:
+            return getattr(value, dunders[0])()
+        raise ValueError(f"Unknown unary operation: {node.op}")
+    if isinstance(node, ast.Name):
+        if node.id in KEYBINDING_FILTERS:
+            return KEYBINDING_FILTERS[node.id]
+        else:
+            sep = "\n  - "
+            known_filters = sep.join(sorted(KEYBINDING_FILTERS))
+            raise NameError(
+                f"{node.id} is not a known shortcut filter."
+                f" Known filters are: {sep}{known_filters}."
+            )
+    raise ValueError("Unhandled node", ast.dump(node))
+
+
+def filter_from_string(code: str):
+    expression = ast.parse(code, mode="eval")
+    return eval_node(expression)
+
+
+__all__ = ["KEYBINDING_FILTERS", "filter_from_string"]
diff --git a/IPython/terminal/tests/test_interactivshell.py b/IPython/terminal/tests/test_interactivshell.py
index 01008d7..ae7da21 100644
--- a/IPython/terminal/tests/test_interactivshell.py
+++ b/IPython/terminal/tests/test_interactivshell.py
@@ -9,9 +9,8 @@ import os
 
 from prompt_toolkit.auto_suggest import AutoSuggestFromHistory
 
-from IPython.core.inputtransformer import InputTransformer
+
 from IPython.testing import tools as tt
-from IPython.utils.capture import capture_output
 
 from IPython.terminal.ptutils import _elide, _adjust_completion_text_based_on_context
 from IPython.terminal.shortcuts.auto_suggest import NavigableAutoSuggestFromHistory
diff --git a/IPython/terminal/tests/test_shortcuts.py b/IPython/terminal/tests/test_shortcuts.py
index 309205d..18c9dab 100644
--- a/IPython/terminal/tests/test_shortcuts.py
+++ b/IPython/terminal/tests/test_shortcuts.py
@@ -11,6 +11,8 @@ from IPython.terminal.shortcuts.auto_suggest import (
     swap_autosuggestion_up,
     swap_autosuggestion_down,
 )
+from IPython.terminal.shortcuts.auto_match import skip_over
+from IPython.terminal.shortcuts import create_ipython_shortcuts
 
 from prompt_toolkit.history import InMemoryHistory
 from prompt_toolkit.buffer import Buffer
@@ -192,18 +194,20 @@ def test_autosuggest_token_empty():
 def test_other_providers():
     """Ensure that swapping autosuggestions does not break with other providers"""
     provider = AutoSuggestFromHistory()
-    up = swap_autosuggestion_up(provider)
-    down = swap_autosuggestion_down(provider)
+    ip = get_ipython()
+    ip.auto_suggest = provider
     event = Mock()
     event.current_buffer = Buffer()
-    assert up(event) is None
-    assert down(event) is None
+    assert swap_autosuggestion_up(event) is None
+    assert swap_autosuggestion_down(event) is None
 
 
 async def test_navigable_provider():
     provider = NavigableAutoSuggestFromHistory()
     history = InMemoryHistory(history_strings=["very_a", "very", "very_b", "very_c"])
     buffer = Buffer(history=history)
+    ip = get_ipython()
+    ip.auto_suggest = provider
 
     async for _ in history.load():
         pass
@@ -211,8 +215,8 @@ async def test_navigable_provider():
     buffer.cursor_position = 5
     buffer.text = "very"
 
-    up = swap_autosuggestion_up(provider)
-    down = swap_autosuggestion_down(provider)
+    up = swap_autosuggestion_up
+    down = swap_autosuggestion_down
 
     event = Mock()
     event.current_buffer = buffer
@@ -254,14 +258,16 @@ async def test_navigable_provider_multiline_entries():
     provider = NavigableAutoSuggestFromHistory()
     history = InMemoryHistory(history_strings=["very_a\nvery_b", "very_c"])
     buffer = Buffer(history=history)
+    ip = get_ipython()
+    ip.auto_suggest = provider
 
     async for _ in history.load():
         pass
 
     buffer.cursor_position = 5
     buffer.text = "very"
-    up = swap_autosuggestion_up(provider)
-    down = swap_autosuggestion_down(provider)
+    up = swap_autosuggestion_up
+    down = swap_autosuggestion_down
 
     event = Mock()
     event.current_buffer = buffer
@@ -316,3 +322,140 @@ def test_navigable_provider_connection():
     session_1.default_buffer.on_text_insert.fire()
     session_2.default_buffer.on_text_insert.fire()
     assert provider.skip_lines == 3
+
+
+@pytest.fixture
+def ipython_with_prompt():
+    ip = get_ipython()
+    ip.pt_app = Mock()
+    ip.pt_app.key_bindings = create_ipython_shortcuts(ip)
+    try:
+        yield ip
+    finally:
+        ip.pt_app = None
+
+
+def find_bindings_by_command(command):
+    ip = get_ipython()
+    return [
+        binding
+        for binding in ip.pt_app.key_bindings.bindings
+        if binding.handler == command
+    ]
+
+
+def test_modify_unique_shortcut(ipython_with_prompt):
+    original = find_bindings_by_command(accept_token)
+    assert len(original) == 1
+
+    ipython_with_prompt.shortcuts = [
+        {"command": "IPython:auto_suggest.accept_token", "new_keys": ["a", "b", "c"]}
+    ]
+    matched = find_bindings_by_command(accept_token)
+    assert len(matched) == 1
+    assert list(matched[0].keys) == ["a", "b", "c"]
+    assert list(matched[0].keys) != list(original[0].keys)
+    assert matched[0].filter == original[0].filter
+
+    ipython_with_prompt.shortcuts = [
+        {"command": "IPython:auto_suggest.accept_token", "new_filter": "always"}
+    ]
+    matched = find_bindings_by_command(accept_token)
+    assert len(matched) == 1
+    assert list(matched[0].keys) != ["a", "b", "c"]
+    assert list(matched[0].keys) == list(original[0].keys)
+    assert matched[0].filter != original[0].filter
+
+
+def test_disable_shortcut(ipython_with_prompt):
+    matched = find_bindings_by_command(accept_token)
+    assert len(matched) == 1
+
+    ipython_with_prompt.shortcuts = [
+        {"command": "IPython:auto_suggest.accept_token", "new_keys": []}
+    ]
+    matched = find_bindings_by_command(accept_token)
+    assert len(matched) == 0
+
+    ipython_with_prompt.shortcuts = []
+    matched = find_bindings_by_command(accept_token)
+    assert len(matched) == 1
+
+
+def test_modify_shortcut_with_filters(ipython_with_prompt):
+    matched = find_bindings_by_command(skip_over)
+    matched_keys = {m.keys[0] for m in matched}
+    assert matched_keys == {")", "]", "}", "'", '"'}
+
+    with pytest.raises(ValueError, match="Multiple shortcuts matching"):
+        ipython_with_prompt.shortcuts = [
+            {"command": "IPython:auto_match.skip_over", "new_keys": ["x"]}
+        ]
+
+    ipython_with_prompt.shortcuts = [
+        {
+            "command": "IPython:auto_match.skip_over",
+            "new_keys": ["x"],
+            "match_filter": "focused_insert & auto_match & followed_by_single_quote",
+        }
+    ]
+    matched = find_bindings_by_command(skip_over)
+    matched_keys = {m.keys[0] for m in matched}
+    assert matched_keys == {")", "]", "}", "x", '"'}
+
+
+def example_command():
+    pass
+
+
+def test_add_shortcut_for_new_command(ipython_with_prompt):
+    matched = find_bindings_by_command(example_command)
+    assert len(matched) == 0
+
+    with pytest.raises(ValueError, match="example_command is not a known"):
+        ipython_with_prompt.shortcuts = [
+            {"command": "example_command", "new_keys": ["x"]}
+        ]
+    matched = find_bindings_by_command(example_command)
+    assert len(matched) == 0
+
+
+def test_modify_shortcut_failure(ipython_with_prompt):
+    with pytest.raises(ValueError, match="No shortcuts matching"):
+        ipython_with_prompt.shortcuts = [
+            {
+                "command": "IPython:auto_match.skip_over",
+                "match_keys": ["x"],
+                "new_keys": ["y"],
+            }
+        ]
+
+
+def test_add_shortcut_for_existing_command(ipython_with_prompt):
+    matched = find_bindings_by_command(skip_over)
+    assert len(matched) == 5
+
+    with pytest.raises(ValueError, match="Cannot add a shortcut without keys"):
+        ipython_with_prompt.shortcuts = [
+            {"command": "IPython:auto_match.skip_over", "new_keys": [], "create": True}
+        ]
+
+    ipython_with_prompt.shortcuts = [
+        {"command": "IPython:auto_match.skip_over", "new_keys": ["x"], "create": True}
+    ]
+    matched = find_bindings_by_command(skip_over)
+    assert len(matched) == 6
+
+    ipython_with_prompt.shortcuts = []
+    matched = find_bindings_by_command(skip_over)
+    assert len(matched) == 5
+
+
+def test_setting_shortcuts_before_pt_app_init():
+    ipython = get_ipython()
+    assert ipython.pt_app is None
+    shortcuts = [
+        {"command": "IPython:auto_match.skip_over", "new_keys": ["x"], "create": True}
+    ]
+    ipython.shortcuts = shortcuts
+    assert ipython.shortcuts == shortcuts
diff --git a/docs/autogen_shortcuts.py b/docs/autogen_shortcuts.py
index f8fd17b..15bb0ee 100755
--- a/docs/autogen_shortcuts.py
+++ b/docs/autogen_shortcuts.py
@@ -1,7 +1,7 @@
 from dataclasses import dataclass
 from inspect import getsource
 from pathlib import Path
-from typing import cast, Callable, List, Union
+from typing import cast, List, Union
 from html import escape as html_escape
 import re
 
@@ -10,7 +10,8 @@ from prompt_toolkit.key_binding import KeyBindingsBase
 from prompt_toolkit.filters import Filter, Condition
 from prompt_toolkit.shortcuts import PromptSession
 
-from IPython.terminal.shortcuts import create_ipython_shortcuts
+from IPython.terminal.shortcuts import create_ipython_shortcuts, create_identifier
+from IPython.terminal.shortcuts.filters import KEYBINDING_FILTERS
 
 
 @dataclass
@@ -44,11 +45,16 @@ class _Invert(Filter):
     filter: Filter
 
 
-conjunctions_labels = {"_AndList": "and", "_OrList": "or"}
+conjunctions_labels = {"_AndList": "&", "_OrList": "|"}
 
 ATOMIC_CLASSES = {"Never", "Always", "Condition"}
 
 
+HUMAN_NAMES_FOR_FILTERS = {
+    filter_: name for name, filter_ in KEYBINDING_FILTERS.items()
+}
+
+
 def format_filter(
     filter_: Union[Filter, _NestedFilter, Condition, _Invert],
     is_top_level=True,
@@ -58,6 +64,8 @@ def format_filter(
     s = filter_.__class__.__name__
     if s == "Condition":
         func = cast(Condition, filter_).func
+        if filter_ in HUMAN_NAMES_FOR_FILTERS:
+            return HUMAN_NAMES_FOR_FILTERS[filter_]
         name = func.__name__
         if name == "<lambda>":
             source = getsource(func)
@@ -66,10 +74,12 @@ def format_filter(
     elif s == "_Invert":
         operand = cast(_Invert, filter_).filter
         if operand.__class__.__name__ in ATOMIC_CLASSES:
-            return f"not {format_filter(operand, is_top_level=False)}"
-        return f"not ({format_filter(operand, is_top_level=False)})"
+            return f"~{format_filter(operand, is_top_level=False)}"
+        return f"~({format_filter(operand, is_top_level=False)})"
     elif s in conjunctions_labels:
         filters = cast(_NestedFilter, filter_).filters
+        if filter_ in HUMAN_NAMES_FOR_FILTERS:
+            return HUMAN_NAMES_FOR_FILTERS[filter_]
         conjunction = conjunctions_labels[s]
         glue = f" {conjunction} "
         result = glue.join(format_filter(x, is_top_level=False) for x in filters)
@@ -104,17 +114,6 @@ class _DummyTerminal:
     auto_suggest = None
 
 
-def create_identifier(handler: Callable):
-    parts = handler.__module__.split(".")
-    name = handler.__name__
-    package = parts[0]
-    if len(parts) > 1:
-        final_module = parts[-1]
-        return f"{package}:{final_module}.{name}"
-    else:
-        return f"{package}:{name}"
-
-
 def bindings_from_prompt_toolkit(prompt_bindings: KeyBindingsBase) -> List[Binding]:
     """Collect bindings to a simple format that does not depend on prompt-toolkit internals"""
     bindings: List[Binding] = []
@@ -178,11 +177,12 @@ def format_prompt_keys(keys: str, add_alternatives=True) -> str:
 
     return result
 
+
 if __name__ == '__main__':
     here = Path(__file__).parent
     dest = here / "source" / "config" / "shortcuts"
 
-    ipy_bindings = create_ipython_shortcuts(_DummyTerminal(), for_all_platforms=True)
+    ipy_bindings = create_ipython_shortcuts(_DummyTerminal())
 
     session = PromptSession(key_bindings=ipy_bindings)
     prompt_bindings = session.app.key_bindings
diff --git a/docs/environment.yml b/docs/environment.yml
index 9961253..9fe7d4a 100644
--- a/docs/environment.yml
+++ b/docs/environment.yml
@@ -16,3 +16,4 @@ dependencies:
     - prompt_toolkit
     - ipykernel
     - stack_data
+    - -e ..
diff --git a/docs/source/config/details.rst b/docs/source/config/details.rst
index 3cc310a..c002d9a 100644
--- a/docs/source/config/details.rst
+++ b/docs/source/config/details.rst
@@ -200,10 +200,20 @@ With (X)EMacs >= 24, You can enable IPython in python-mode with:
 Keyboard Shortcuts
 ==================
 
+.. versionadded:: 8.11
+
+You can modify, disable or modify keyboard shortcuts for IPython Terminal using
+:std:configtrait:`TerminalInteractiveShell.shortcuts` traitlet.
+
+The list of shortcuts is available in the Configuring IPython :ref:`terminal-shortcuts-list` section.
+
+Advanced configuration
+----------------------
+
 .. versionchanged:: 5.0
 
-You can customise keyboard shortcuts for terminal IPython. Put code like this in
-a :ref:`startup file <startup_files>`::
+Creating custom commands requires adding custom code to a
+:ref:`startup file <startup_files>`::
 
     from IPython import get_ipython
     from prompt_toolkit.enums import DEFAULT_BUFFER
diff --git a/docs/source/config/shortcuts/index.rst b/docs/source/config/shortcuts/index.rst
index e361ec2..42fd6ac 100755
--- a/docs/source/config/shortcuts/index.rst
+++ b/docs/source/config/shortcuts/index.rst
@@ -1,8 +1,10 @@
+.. _terminal-shortcuts-list:
+
 =================
 IPython shortcuts
 =================
 
-Available shortcuts in an IPython terminal.
+Shortcuts available in an IPython terminal.
 
 .. note::
 
@@ -12,7 +14,10 @@ Available shortcuts in an IPython terminal.
 
 * Comma-separated keys, e.g. :kbd:`Esc`, :kbd:`f`, indicate a sequence which can be activated by pressing the listed keys in succession.
 * Plus-separated keys, e.g. :kbd:`Esc` + :kbd:`f` indicate a combination which requires pressing all keys simultaneously.
-* Hover over the ⓘ icon in the filter column to see when the shortcut is active.g
+* Hover over the ⓘ icon in the filter column to see when the shortcut is active.
+
+You can use :std:configtrait:`TerminalInteractiveShell.shortcuts` configuration
+to modify, disable or add shortcuts.
 
 .. role:: raw-html(raw)
    :format: html
diff --git a/docs/source/whatsnew/pr/shortcuts-config-traitlet.rst b/docs/source/whatsnew/pr/shortcuts-config-traitlet.rst
new file mode 100644
index 0000000..8d3ce11
--- /dev/null
+++ b/docs/source/whatsnew/pr/shortcuts-config-traitlet.rst
@@ -0,0 +1,21 @@
+Terminal shortcuts customization
+================================
+
+Previously modifying shortcuts was only possible by hooking into startup files
+and practically limited to adding new shortcuts or removing all shortcuts bound
+to a specific key. This release enables users to override existing terminal
+shortcuts, disable them or add new keybindings.
+
+For example, to set the :kbd:`right` to accept a single character of auto-suggestion
+you could use::
+
+    my_shortcuts = [
+        {
+            "command": "IPython:auto_suggest.accept_character",
+            "new_keys": ["right"]
+        }
+    ]
+    %config TerminalInteractiveShell.shortcuts = my_shortcuts
+
+You can learn more in :std:configtrait:`TerminalInteractiveShell.shortcuts`
+configuration reference.
\ No newline at end of file