diff --git a/IPython/terminal/shortcuts/__init__.py b/IPython/terminal/shortcuts/__init__.py
index d287368..ad4dc39 100644
--- a/IPython/terminal/shortcuts/__init__.py
+++ b/IPython/terminal/shortcuts/__init__.py
@@ -343,8 +343,9 @@ def create_ipython_shortcuts(shell, for_all_platforms: bool = False) -> KeyBindi
     kb.add("c-right", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
         auto_suggest.accept_token
     )
-    from functools import partial
-
+    kb.add("escape", filter=has_suggestion & has_focus(DEFAULT_BUFFER), eager=True)(
+        auto_suggest.discard
+    )
     kb.add("up", filter=has_suggestion & has_focus(DEFAULT_BUFFER))(
         auto_suggest.swap_autosuggestion_up(shell.auto_suggest)
     )
diff --git a/IPython/terminal/shortcuts/auto_suggest.py b/IPython/terminal/shortcuts/auto_suggest.py
index a8e1d7b..733a46d 100644
--- a/IPython/terminal/shortcuts/auto_suggest.py
+++ b/IPython/terminal/shortcuts/auto_suggest.py
@@ -167,6 +167,12 @@ def accept(event: KeyPressEvent):
         nc.forward_char(event)
 
 
+def discard(event: KeyPressEvent):
+    """Discard autosuggestion"""
+    buffer = event.current_buffer
+    buffer.suggestion = None
+
+
 def accept_word(event: KeyPressEvent):
     """Fill partial autosuggestion by word"""
     buffer = event.current_buffer
diff --git a/IPython/terminal/tests/test_shortcuts.py b/IPython/terminal/tests/test_shortcuts.py
index 9f15843..a43a4ba 100644
--- a/IPython/terminal/tests/test_shortcuts.py
+++ b/IPython/terminal/tests/test_shortcuts.py
@@ -6,6 +6,7 @@ from IPython.terminal.shortcuts.auto_suggest import (
     accept_character,
     accept_word,
     accept_and_keep_cursor,
+    discard,
     NavigableAutoSuggestFromHistory,
     swap_autosuggestion_up,
     swap_autosuggestion_down,
@@ -49,6 +50,22 @@ def test_accept(text, suggestion, expected):
 
 
 @pytest.mark.parametrize(
+    "text, suggestion",
+    [
+        ("", "def out(tag: str, n=50):"),
+        ("def ", "out(tag: str, n=50):"),
+    ],
+)
+def test_discard(text, suggestion):
+    event = make_event(text, len(text), suggestion)
+    buffer = event.current_buffer
+    buffer.insert_text = Mock()
+    discard(event)
+    assert not buffer.insert_text.called
+    assert buffer.suggestion is None
+
+
+@pytest.mark.parametrize(
     "text, cursor, suggestion, called",
     [
         ("123456", 6, "123456789", True),