diff --git a/IPython/core/async_helpers.py b/IPython/core/async_helpers.py
index fb4cc19..fca78de 100644
--- a/IPython/core/async_helpers.py
+++ b/IPython/core/async_helpers.py
@@ -13,19 +13,29 @@ Python semantics.
 
 import ast
 import sys
+import asyncio
 import inspect
 from textwrap import dedent, indent
 
 
 class _AsyncIORunner:
+    def __init__(self):
+        self._loop = None
+
+    @property
+    def loop(self):
+        """Always returns a non-closed event loop"""
+        if self._loop is None or self._loop.is_closed():
+            policy = asyncio.get_event_loop_policy()
+            self._loop = policy.new_event_loop()
+            policy.set_event_loop(self._loop)
+        return self._loop
 
     def __call__(self, coro):
         """
         Handler for asyncio autoawait
         """
-        import asyncio
-
-        return asyncio.get_event_loop().run_until_complete(coro)
+        return self.loop.run_until_complete(coro)
 
     def __str__(self):
         return 'asyncio'
diff --git a/IPython/core/tests/test_interactiveshell.py b/IPython/core/tests/test_interactiveshell.py
index 84bea9c..598b6dc 100644
--- a/IPython/core/tests/test_interactiveshell.py
+++ b/IPython/core/tests/test_interactiveshell.py
@@ -1037,6 +1037,22 @@ def test_run_cell_async():
     assert result.result == 5
 
 
+def test_run_cell_await():
+    ip.run_cell("import asyncio")
+    result = ip.run_cell("await asyncio.sleep(0.01); 10")
+    assert ip.user_ns["_"] == 10
+
+
+def test_run_cell_asyncio_run():
+    ip.run_cell("import asyncio")
+    result = ip.run_cell("await asyncio.sleep(0.01); 1")
+    assert ip.user_ns["_"] == 1
+    result = ip.run_cell("asyncio.run(asyncio.sleep(0.01)); 2")
+    assert ip.user_ns["_"] == 2
+    result = ip.run_cell("await asyncio.sleep(0.01); 3")
+    assert ip.user_ns["_"] == 3
+
+
 def test_should_run_async():
     assert not ip.should_run_async("a = 5")
     assert ip.should_run_async("await x")
diff --git a/IPython/terminal/interactiveshell.py b/IPython/terminal/interactiveshell.py
index 1ea9e7e..4e35aad 100644
--- a/IPython/terminal/interactiveshell.py
+++ b/IPython/terminal/interactiveshell.py
@@ -460,13 +460,15 @@ class TerminalInteractiveShell(InteractiveShell):
         # If we don't do this, people could spawn coroutine with a
         # while/true inside which will freeze the prompt.
 
+        policy = asyncio.get_event_loop_policy()
         try:
-            old_loop = asyncio.get_running_loop()
+            old_loop = policy.get_event_loop()
         except RuntimeError:
-            # This happens when the user used `asyncio.run()`.
+            # This happens when the the event loop is closed,
+            # e.g. by calling `asyncio.run()`.
             old_loop = None
 
-        asyncio.set_event_loop(self.pt_loop)
+        policy.set_event_loop(self.pt_loop)
         try:
             with patch_stdout(raw=True):
                 text = self.pt_app.prompt(
@@ -474,7 +476,8 @@ class TerminalInteractiveShell(InteractiveShell):
                     **self._extra_prompt_options())
         finally:
             # Restore the original event loop.
-            asyncio.set_event_loop(old_loop)
+            if old_loop is not None:
+                policy.set_event_loop(old_loop)
 
         return text