diff --git a/development.ini b/development.ini
--- a/development.ini
+++ b/development.ini
@@ -117,6 +117,15 @@ use_htsts = false
 ## number of commits stats will parse on each iteration
 commit_parse_limit = 25
 
+## Path to Python executable to be used for git hooks.
+## This value will be written inside the git hook scripts as the text
+## after '#!' (shebang). When empty or not defined, the value of
+## 'sys.executable' at the time of installation of the git hooks is
+## used, which is correct in many cases but for example not when using uwsgi.
+## If you change this setting, you should reinstall the Git hooks via
+## Admin > Settings > Remap and Rescan.
+# git_hook_interpreter = /srv/kallithea/venv/bin/python2
+
 ## path to git executable
 git_path = git
 
diff --git a/kallithea/lib/paster_commands/template.ini.mako b/kallithea/lib/paster_commands/template.ini.mako
--- a/kallithea/lib/paster_commands/template.ini.mako
+++ b/kallithea/lib/paster_commands/template.ini.mako
@@ -211,6 +211,18 @@ use_htsts = false
 <%text>## number of commits stats will parse on each iteration</%text>
 commit_parse_limit = 25
 
+<%text>## Path to Python executable to be used for git hooks.</%text>
+<%text>## This value will be written inside the git hook scripts as the text</%text>
+<%text>## after '#!' (shebang). When empty or not defined, the value of</%text>
+<%text>## 'sys.executable' at the time of installation of the git hooks is</%text>
+<%text>## used, which is correct in many cases but for example not when using uwsgi.</%text>
+<%text>## If you change this setting, you should reinstall the Git hooks via</%text>
+<%text>## Admin > Settings > Remap and Rescan.</%text>
+# git_hook_interpreter = /srv/kallithea/venv/bin/python2
+%if git_hook_interpreter:
+git_hook_interpreter = ${git_hook_interpreter}
+%endif
+
 <%text>## path to git executable</%text>
 git_path = git
 
diff --git a/kallithea/model/scm.py b/kallithea/model/scm.py
--- a/kallithea/model/scm.py
+++ b/kallithea/model/scm.py
@@ -727,8 +727,11 @@ class ScmModel(object):
         Git hook scripts so they invoke Kallithea code with the right Python
         interpreter and in the right environment.
         """
+        # Note: sys.executable might not point at a usable Python interpreter. For
+        # example, when using uwsgi, it will point at the uwsgi program itself.
         # FIXME This may not work on Windows and may need a shell wrapper script.
-        return (sys.executable
+        return (kallithea.CONFIG.get('git_hook_interpreter')
+                or sys.executable
                 or '/usr/bin/env python2')
 
     def install_git_hooks(self, repo, force_create=False):